Rhodococcus equi: Conversion of a saprophyte bacterium into an intracellular pathogen
نویسندگان
چکیده
منابع مشابه
Rhodococcus equi: an emerging pathogen.
More than 100 cases of Rhodococcus equi infection have been reported since the first description of human disease caused by this organism. The vast majority of patients infected with R. equi are immunocompromised, and two-thirds have human immunodeficiency virus infection. The clinical manifestations of R. equi infection are diverse, although 80% of patients have some pulmonary involvement. The...
متن کاملRhodococcus equi: an animal and human pathogen.
Recent isolations of Rhodococcus equi from cavitatory pulmonary disease in patients with AIDS have aroused interest among medical microbiologists in this unusual organism. Earlier isolations from humans had also been in immunosuppressed patients following hemolymphatic tumors or renal transplantation. This organism has been recognized for many years as a cause of a serious pyogranulomatous pneu...
متن کاملThe intracellular pathogen Rhodococcus equi produces a catecholate siderophore required for saprophytic growth.
Little is known about the iron acquisition systems of the soilborne facultative intracellular pathogen Rhodococcus equi. We previously reported that expression of iupABC, encoding a putative siderophore ABC transporter system, is iron regulated and required for growth at low iron concentrations. Here we show that disruption of iupA leads to the concomitant accumulation of catecholates and a chr...
متن کاملIsocitrate lyase activity is required for virulence of the intracellular pathogen Rhodococcus equi.
Rhodococcus equi is an important pathogen of foals, causing severe pyogranulomatous pneumonia. Virulent R. equi strains grow within macrophages, a process which remains poorly characterized. A potential source of carbon for intramacrophage R. equi is membrane lipid-derived fatty acids, which following beta oxidation are assimilated via the glyoxylate bypass. To assess the importance of isocitra...
متن کاملStructure of the virulence-associated protein VapD from the intracellular pathogen Rhodococcus equi
Rhodococcus equi is a multi-host pathogen that infects a range of animals as well as immune-compromised humans. Equine and porcine isolates harbour a virulence plasmid encoding a homologous family of virulence-associated proteins associated with the capacity of R. equi to divert the normal processes of endosomal maturation, enabling bacterial survival and proliferation in alveolar macrophages. ...
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ژورنال
عنوان ژورنال: Journal of Equine Veterinary Science
سال: 2016
ISSN: 0737-0806
DOI: 10.1016/j.jevs.2016.02.178